The ancient fortified village of Isola del Gran Sasso is located on the northeastern slopes of the Gran Sasso massif. It has excellent views of the Corno Grande, and is called 'Isola' (island) because it is wedged between two rivers, the Mavone and the Ruzzo torrent. Even after a very long, hot summer, the sounds of splashing water still lend a fresh, atmospheric air to the town.

Isola del Gran Sasso is the start point for walks up the mountain. There is also a lovely walk to the Castle of Pagliara. The remains of the ancient castle are found on a steep slope at 980m above sea level. Today's remains still show the layout of the ancient castle. Nearby the Church of Santa Maria a Pagliara are almost intact.

Near to Isola is one of the most important and popular sanctuaries in Abruzzo, San Gabriele dell'Addolorata. Isola del Gran Sasso and San Gabriele are only 20 minutes from Villa Mandorla.

The defensive walls of the medieval centre of the town are still visible in parts. Along Via Duca degli Abruzzi there is a surviving castrum gate, Porta Canapina. Along Via Romea there is a massive remodelled defence tower, which has a round arch gate known as Porta del Torrione.